Mixed lymphocyte culture determinants and C2 deficiency: LD-7a associated with C2 deficiency in four families.

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Mixed lymphocyte culture determinants and C2 deficiency: LD-7a associated with C2 deficiency in four families

Four families with C2 deficiency were studied. Among eight HL-A haplotypes involved with C2 deficiency, five were HL-A 10,W18. Three homozygotes for C2 deficiency from different families were mutually nonreactive in mixed lymphocyte cultures (MLC) and the heterozygotes from the fourth family failed to react to the homozygous cells. It appeared that identical MLC determinants were associated ...

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Rheumatological manifestations, organ damage and autoimmunity in hereditary C2 deficiency.

OBJECTIVE To analyse rheumatological manifestations, organ damage and autoimmune responses in a large cohort of patients (n = 45) with homozygous C2 deficiency (C2D) and long-term follow-up. METHODS Medical records were reviewed and were supplemented with a mailed questionnaire for assessment of cardiovascular disease (CVD) risk factors. Organ damage was evaluated using the Systemic Lupus Int...

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HLA-Cw alleles associated with HLA extended haplotypes and C2 deficiency.

There are four MHC-linked complement genes, BF, C2, C4A and C4B, that are inherited as single DNA units, known as complotypes. Extended haplotypes were initially defined by studying the distribution of complotypes in relation to HLA-B and HLA-DR loci in Caucasian families. In order to analyze the distribution of HLA-Cw alleles in relation to extended haplotypes, we studied a large panel of MHC ...

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Heterozygous C2 deficiency associated with angioedema, myasthenia gravis, and systemic lupus erythematosus.

We describe a patient with myasthenia gravis, systemic lupus erythematosus, and angioedema associated with heterozygous complement factor 2 (C2) deficiency. The significance of this association is controversial, though the association of C2 deficiency with certain histocompatibility antigens suggests possible linkage to immune response genes. To our knowledge this is the first report of heteroz...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1975

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.142.2.495